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The outcome in the oral-prednisone group did not differ from that in the placebo group.In addition,the rate of new episodes of optic neuritis in either eye was higher in the group receiving oral prednisone,but not the group receiving intravenous methylprednisolone,than in the placebo group (relative risk for oral prednisone vs.placebo,1.79;95 percent confidence interval,1.08 to 2.95).Intravenous methylprednisolone followed by oral prednisone speeds the recovery of visual loss due to optic neuritis and results in slightly better vision at six months.Oral prednisone alone,as prescribed in this study,is an ineffective treatment and increases the risk of new episodes of optic neuritis. |
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